Screening of the melanin synthesis inhibitory action of the test sample is conducted with in vitro tests, enabling phased development of components effective for skin whitening from elucidation of the action mechanism through to in vivo tests using human subjects.
|in vivo (human clinical test)
|in vitro (using cells and 3D models)
（evaluation of spot improvement effect)
|Evaluation focused on tyrosinase
|Melanin synthesis inhibition test