Company Infomation

Nikoderm Research Inc. 






Address   :        1-6-14 Azuchimachi,Chuo-ku,Osaka City,

                        OSAKA 541-0052,JAPAN

TEL         :       +81-6-6125-3501

FAX         :       +81-6-6125-3530

E-mail       :

Representative  Daiki Kyotani,President







Safty/efficacy evaluation of cosmetics/pharmaceutical raw materrials and preparations

Proposal of appropriate evaluation methods




Main Service

Undertakes the following evaluations consultations related to evaluation.


Safety evaluation

::   ●Animal testing alternative:Irritation,Photoxicity,Ocular irritation

::   ●Human object test :Primary skin irritation,Skin sensitization,Stionging test.


Evaluation on preservative system

::   anti-bacterial activity test


Efficacy evaluation::

::   In vitro test;Cell activations,Cell proliferation,Oxidative stress resistance,

::     Collagen synthesis,Hyaluronic acid synthesisi,MMP-1 synthesis,Elastase activity,

           Tyrosinase activity,Melanogenesis,Tyrosinase synthesis


::   In vivo test:Physiological effects on the skin,Skin lightening,Anti-wrinkle,

           Hair growing,Effects of long-term application of cosmetics,SPF/PA measurement


Sale of reconstructed 3-D models(SkinEthic Laboratoratories) in Japan:

::   Reconstructed human epidermal models(Episkin,RHE)

::   Reconstructed human pigmented model(RHPE)

::   Reconstructed human cornel epithelial model(HCE)

        Nikoderm also performs safety and efficacy evaluations using the abovementioned models.




2003 Establishment of Nikoderm Research Inc.

2004 Installation of evaluation rooms and cell culture rooms in Head Office

2009 Conclusion of agreement with SkinEthic Laboratories,France,as its exclusive agent in Japan